Evaluating one-pot synthesis of 3,5-substituted hydantoins and their biological studies

The present paper describes studies on the synthesis of 3,5‐substituted imidazolidine-2,4-dione via Mannich reaction between various secondary amines and hydantoin derivatives. For all compounds NOE (Nuclear Overhauser Effect) NMR spectra were deliberate in order to confirm additionally the position of the substituent in the imidazolidine- 2,4-dione ring. Some physiochemical and electronic properties of the compounds were determined in order to found the resemblance between the synthesized and reference compounds. All the compounds were also characterized by 13C NMR, FT-IR and LC/MS mass spectrum. All the newly synthesized compounds were screened for their in vitro antimicrobial activity and many of them found to show similar activity to the standard drug with different microorganisms

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