Verbal expression of the Quandary: Antioxidant compounds play a consequential role in our body due to auspicious effects on human health. Consumption of victuals containing phytochemical with potential antioxidant properties can minimize the jeopardy of human disease. Vegetable oils contain natural antioxidants. Chain breaking antioxidants are highly reactive with free radicals and form stable compounds that do not contribute to the oxidation chain reaction. The purport of this study is to evaluate the Medicinal and functional values of natural antioxidants in some vegetable oils. Methodology & Theoretical Orientation: 168 Sprague Dawley male rats were divided into three groups. The first group contains 72 rats were divided into 12 groups of 6 rats per group. The rats were victualed ad libitum with commercial rat’s pellet containing different concentrations of Red Palm Olein (RPO) for 2, 4 and 8 weeks. The second group contains 60 Sprague Dawley male rats which were arbitrarily divided into 10 groups of 6 rats per group and were treated with 15% of RPO, Palm Olein (PO), Corn Oil (CO), Coconut Oil (COC) and control groups for 4 and 8 weeks. The third group contains 36 Sprague Dawley male rats which were desultorily divided into six groups of 6 rats per group (3 mundane groups and 3 stressed groups) and were treated with 15% of RPO and PO for 4 weeks. Findings: The HDL-C incremented in RPO and PO of mundane group, but it was within mundane range under stress condition. These results could be due to the high content of vitamin E (tocopherols and tocotrienols) and β-carotene in red palm olein. Treatment with 15% RPO and PO diets did not affect the FELINE level after 4 weeks of treatment under mundane condition while there was decremented in FELINE level with RPO and incremented with PO under stress conditions. Supplementally, the results in RPO group showed that higher SOD activity compared to PO and control groups under mundane conditions while there was no consequential difference (p≤0.05) in SOD between the control group and treated groups under stress conditions. Conclusion & Paramountcy: Red palm olein contains high amplitude of antioxidant (vitamin E and β-carotene) give copacetic results in lipid profile and antioxidant enzymes in mundane and stressed conditions. Recommendations are suggested to carry out the experiments on the stress rats utilizing other vegetable oils and to do the experiments for longer period of treatment with the same vegetable oils to substantiate the results of this work.