The present order of diabetes into type 1and sort 2 depends on insulin reliance and falls behind major logical advances in sub-atomic bases of pathobiological forms. In this way, there is a need to consolidate progressed biomedical translational research discoveries to the requests of accuracy medication. Incorporated various systems of phenotyping and genotyping affiliations by means of sub-atomic profiling and interactome systems may improve diabetes particularity and sub-atomic diversity.Rapid enormous advancement in diabetes genomics, epigenomics, proteomics, transcriptomics and metabolomics prompts revelation of novel biomarkers and adjusts our comprehension of diabetes pathobiology, infection movement and its complexities. Therefore, numerous novel enemy of diabetic medications are endorsed during the previous two decades with radiant cardioprotective and renoprotective favorable circumstances outside glycemic ability to control. Future potential effects of accuracy medication in determination and treatment of type 2 diabetes are talked about. The new patterns in the administration of mongenic diabetes that best represents ramifications of accuracy medication in diabetes the board are talked about. Anyway there stay a few difficulties, obstacles and restrictions, for example, large information examination of diabetic phenotypic information normalization in electronic wellbeing records and the requirement for progresses in computational sciences, biostatistics and imaginative programming projects to fill the holes in phenotypic and genotyping information relationship by further looks into. Advances in diabetes clinical bioinformatics, sub-atomic bioinformatics and radiomics are proposed and examined. Enormous centralization of exactness medication is given to oncology in past decades that depends for the most part on unadulterated genomics with significant revelations of novel enemy of malignant growth medicines, explains the significance of extending it to diabetes and other normal constant illnesses for improving exact preventive, indicative, chance delineation, prognostic and sub-atomic restorative modalities.