E-BABE-Numerical Investigations of Liver-on-a-chip platforms

Miniaturized culture systems of hepatic cells are emerging as a strong tool facilitating studies related to liver diseases and drug discovery. However, the experimental optimization of various parameters involved in the operation of these systems is time-consuming and expensive. Hence, developing numerical tools predicting the function of such systems can significantly reduce the associated cost. In this presentation, some of the developed mathematical models of liver-on-a-chip platforms will be disscused. The numerical models includes design and optimization of microfluicis, metabolic model for prediction of some of the cellular activities and some related disease modeling. The obtained results could be beneficial in providing the suitable and optimized conditions for future in vitro experiments. The presented numerical models provides a numerical platform which can help researchers to design and optimize complex bioreactors and obtain numerical indexes of the main metabolites in a very short time prior to any fabrications. Such numerical indexes can be helpful in certifying the outcomes of forensic investigations.

Author(s): Fatemeh Sharifi

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