Development and Validation of Spectrophotometric Method for the Determination of Perindopril Erbumine in Bulk Dosage Form

A simple, accurate, cost effective and reproducible spectrophotometric method has been developed for the estimation of perindopril erbumine in bulk and pharmaceutical dosage form. UV spectrophotometric method, which is based on measurement of absorption at maximum wavelength 213nm. The developed method was validated with respect to accuracy, linearity, precision, limit of detection, limit of quantification and Sandell’s sensitivity. Beers law was obeyed in the concentration range of 4-16μg/ml having line equation Y=0.01350X+0.05879 with correlation coefficient of 0.998. Results of the analysis were validated statistically.

Author(s): Ratnaparkhi Mukesh, Patil Pradeep, Jagadale Sachin

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