Development and Validation of UV/Visible Spectrophotometric Method for the Estimation of Rifapentine in Bulk and Pharmaceutical Formulations

A simple, accurate, precise and sensitive UV/visible spectrophotometric method were developed for the determination of Rifapentine in bulk and pharmaceutical dosage form. The solvent used was methanol and the wavelength corresponding to maximum absorbance of the drug was found at 478nm. Drug obey’s Beers law in the concentration range of 10- 60ug/ml with correlation coefficient 0.9997. The linear regression equation obtained by least square regression method was y=0.0107x-0.0333, where y is the absorbance and x is the concentration of the pure drug solution. The method was validated for several parameters like accuracy, precision as per ICH guidelines. The values of relative standard deviation and % recovery were found to be satisfactory, indicating that the proposed method is precise and accurate and hence can be used for the routine analysis of Rifapentine in bulk and pharmaceutical formulation.

Author(s): Ansari Tahir, Kalkotwar R.S, Jeevan Naikwade & Afsar Shaikh

Abstract | PDF

Share This Article
30+ Million Readerbase
Google scholar citation report
Citations : 1921

American Journal of Phytomedicine and Clinical Therapeutics received 1921 citations as per google scholar report

Abstracted/Indexed in
  • Google Scholar
  • Sherpa Romeo
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • Open Academic Journals Index (OAJI)
  • Directory of Research Journal Indexing (DRJI)
  • Publons
  • Scientific Journal Impact Factor
  • International Committee of Medical Journal Editors (ICMJE)
  • Secret Search Engine Labs
  • Euro Pub

View More »

Flyer image