Background: Dento-maxillary disharmony is a disproportion between the size or the mesiodistal diameter of theteeth and the perimeter of the corresponding alveolar arches. The objective of this study is to describe frequency andmanagement of default dento-maxillary disharmonies in the department of Odontostomatology of Donka National Hospital. This was a descriptive prospective study with all patients seeking dental care at the department of Odontostomatology ofDonka National Hospital. The study was conducted over 13 months from June 2016 to 30 June 2017. Among the 485 patients seeking dental care, the frequency of dento-maxillary disharmonies was 7.21%. The mean age of patients was 8.75 years, withextreme ages of 7 and 26 years. Females were the most represented with 77.15% that is a sex ratio of 0.29. The upper arch wasthe most concerned by the dento-maxillary disharmony with a proportion of 57.14%. The orthodontic treatment was the common est treatment with 57.14%. Dento-maxillary disharmony had many clinical signs that allowed the practitioner makingearly diagnosis. Early management could help remodeling the bone genome and reducing the risk of relapse, and the length oforthodontic treatment.