Cyclic Voltammetric determination of 1, 4-Dihydro pyridine drugs using MWCNTs modified glassy carbon electrode

MWCNTs are believed to be favorable for the oxidation of electroactive species towards cathodic direction with the simultaneous enhancement of the peak current. The prepared electrode showed an excellent electrocatalytic activity towards the oxidation of antihypertensive drugs leading to a marked improvement in sensitivity. The MWCNTsmodified GCE exhibited a sharp anodic peak around 0.6 V peak potential for Lercanidipine (LERD) and 0.4 V peak potential for Nifedipine (NIFD) in the cyclic voltammograms. The antihypertensive drugs were determined by using a simple two-step procedure developed which comprised a preconcentration step followed by the differential pulse voltammetric quantification. Concentration calibrations were linear within the range from 0.02 to 0.3 mg /mL for LERD and 0.025 to 0.3 mg /mL for NIFD. The lower limits detection (LOD) was found to be very low on modified electrode. An electrochemical sensor featuring the MWCNTs-modified electrode was applied successfully for the 1, 4-dihydropyridines determination in pharmacutical samples

Author(s): Mohamed Sikkander, C. Vedhi and P. Manisankar

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