Objectives: The present study was designed to explore the protective effect of Cassia auriculata L. flower extract (CAE) in high fat diet and streptozotocin induced type 2 diabetic (T2DM) rats. Methods: T2DM was induced by a combination of high fat diet and low dose streptozocin. Rats in different groups were treated with Cassia auriculata L. flower extract at two different doses viz. 300mg and 500mg/Kg body weight and the hypoglycemic potential as well as lipid lowering and antioxidant properties of CAE in liver and pancreas were evaluated. Results: T2DM rats showed significantly elevated glucose and reduced c-peptide levels in serum. Also there was significant increase in serum marker enzymes of liver toxicity-alanine transaminase (SGPT), aspartate transaminase (SGOT) and alkaline phosphatase (ALP) along with significant reduction in liver glycogen and increase in lipid peroxidation levels. There was also deregulation in lipid levels in plasma and liver and significant reduction in antioxidant enzymes in plasma, liver and pancreas. Encouragingly, treatment with Cassia auriculata extract caused significant improvement in the glucose, insulin, lipid levels in plasma and the antioxidant status of liver and pancreas.
Conclusion: Out of the two doses of CAE used in this study, 500mg/kg b.w dose was found to be more effective in regulating the levels of antioxidants and lipid levels in plasma, liver and pancreas indicating its potential to ameliorate peripheral insulin resistance.