Vaccines are the most effective defensive measure toward the various infectious diseases, work by boosting the immune system with the production of proteins called antibodies to recognize and fight hard against deadly pathogens. Human Immunodeficiency Virus (HIV-1) is one of the deadly infection and threat to the society with ~37 million people currently being infected worldwide. Thus, there is high demand to develop a suitable HIV vaccine for this pandemic disease. Although more insight and progress has been made towards the vaccine development but so far the efforts are futile. Since the advent of antiretroviral therapy (ART), the life expectancy of HIV infected patients can be extended and improved but vaccine will be the ultimate solution to this serious issue.