Biochemical Effect of Nepeta Septemcrenata Growing in South Sinai, Egypt

The present study aims to at investigate the effect of ethanolic extract of Nepetaseptemcrenata on lipid peroxidation and antioxidant defenses, the activities of three lysosmal acid hydrolases and the total protein, DNA and RNA contaent and Hepatic and kidney functions. In this study, three main tests were investigated including; Pharmachological effect of the plant extraction, Biochemical effect of the ethanolic extract and Effect of Nepetaseptemcrenata ethanolic extract on liver lysosomal enzymes, total protein, DNA and RNA. The results reviewed that antipyretic effect is the decreasing of the temperature of the hyperthermic rats, theethanolic extract of Nepetaseptemcenata which given interperotential to rats with inflamed paw in a dose of (1/5 LD50 & 1/10 LD50) significantly decreased the thickness of the inflamed rats' paw as compared with the control group and standard group after 6 hours. The ethanolic extract of Nepetaseptemcrenata in a dose of 1.1 and 50.5 mg/kg, induced protection against writhing response andreaches its maximum effect in a dose of 1.1 mg/kg. In theAntibacterial activity the investigation of antimicrobial activities of Nepetaseptemcrenataextract revealed that it has no activity against S. aureus and a very weak antiseptic action against E. coli. Finally, Nepetaseptemcrenata hasmuch medicinal prosperity.

Author(s): Abd El-Raouf A. Moustafa*, HamdyAbd El-Azeem, Mohamed A. Omran, Sawsan A. M. Nasr, Ismail M. Abdel-Nabi, Zakaria A. Teleb

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