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Biochemical and histopathological analysis of aflatoxin induced toxicity in liver and kidney of rat

The present investigation was an attempt to evaluate the effect of aflatoxin induced toxicity in liver and kidney of albino rats. Aflatoxin was obtained by growing Aspergillus flavus in PDA liquid medium. Young adult albino rat were administered aflatoxin through intraperitoneal route by different concentrations viz., 20 ppm, 40 ppm, 60 ppm, 80 ppm and 100 ppm for 8 days. On 9th day the animals were sacrificed by cervical dislocation. Liver and kidney were removed and Homogenates were prepared for measuring lipid peroxidation, lactate dehydrogenase, superoxide dimutase, catalase, Glutathione peroxidase, glutathione reductase, glutathione stransferase, alkaline phosphatase, glucose 6-phosphatase, Fructose 1, 6-bisphosphate, vitamin C, vitamin E, sodium, potassium and uric acid. The results revealed concentration dependent increase in lipid peroxidation and alkaline phosphatase along with reduction in enzymatic and non-enzymatic antioxidants. Hence they have shown that concurrent infection during aflatoxin exposure increase the risk of hepatocellular carcinoma.

Author(s): G. Devendran and U. Balasubramanian

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