Abstract

(Beneficial effects of Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Clinical Trial)

Background: Despite recent interest in the use of ketogenic diets (KDs) for cancer, evidence of beneficial effects is lacking. The present study aimed to evaluate the effects of a KD in patients with locally advanced and metastatic breast cancer receiving chemotherapy. Methods: A total of 80 patients undergoing treatment with chemotherapy were randomly assigned to KD or control group for 12 weeks. Concurrent with the admission, midway point, and at 12 weeks, fasting blood samples were collected for evaluation of kidney and liver markers, lipid profile, FBS, ketone bodies, insulin, IGF-1, CEA, CA15- 3, ESR, CRP, IL-10, and TNF-a. Quality of life and physical activity were assessed. Sonography for patients with locally advanced disease and CT or MRI scans for patients with metastatic disease were done on admission and at 12 weeks. At the completion of the chemotherapy, patients with locally advanced disease underwent surgery and stage was recalculated. Also patients with metastases were evaluated for response rate.


Author(s): Adeleh Khodabakhshi  

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