Abstract

Association of HMOX-1 with sporadic Alzheimer's disease in southern Han Chinese

Study objectives: To discover the associations between HMOX-1 and Alzheimer’s disease (AD).
Methods: 500 AD patients and 500 healthy controls were recruited in this study. AD was diagnosed by neurologist specialized in dementia base on NINCDS-ADRDA criteria. Blood samples from AD patients and healthy controls were used for DNA extraction and Polymer chain reaction (PCR).Student t test and Chi-square analysis was used for statistical analysis.
Results: The dominant model and the recessive model of HMOX-1 rs2071746 were shown statistically significant between AD patients and control after adjustment of age, gender and education (Dominant model: p value: 0.047, OR: 1.34, 95% CI: 1.00 – 1.78, adjusted; recessive model: p value: 0.049, OR: 1.34, 95% CI: 1.00 – 1.80, adjusted). There is also a trend of association between dominant model and LOAD after adjustment of age, gender and education (Dominant model: p value: 0.084, OR: 1.37, 95% CI: 0.96 – 1.95, adjusted).


Author(s): Hongxiang Yu

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