Antioxidant Activity of Polyherbal Formulation on Streptozotocin Induced Diabetes in Experimental Animals

ESF/AY/250 and ESF/AY/500 polyherbal formulation intended to use for diabetic patients has been screened for antioxidant activity. For antioxidant studies, both were administered orally for 45 days at a dose of 250mg and 500mg/kg body weight to Streptozotocin induced diabetic male Wistar rats. All the animals were sacrificed on the 45^th day and the levels of LPO, SOD, CAT, GPx & GSH in kidney and liver of control and experimental rats were studied. The poly herbal formulation exhibited significant antioxidant activity showing increased levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and reduced glutathione (GSH) and decreased level of lipid peroxidation. These results showed that treatment with ESF/AY/250 and ESF/AY/500 lowers Streptozotocin induced Lipid per oxidation and alters SOD, CAT, GPx and GSH enzymes to reduce oxidative stress.

Author(s): Sajeeth CI, Manna PK and Manavalan R

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