Antinociceptive Potential of Terminalia Catappa (Indian Almond) Leaves in Swiss Albino Rat

Terminalia catappa (almond) is a combretaceous plant whose leaves are widely used as a folk medicine for treatments of dermatitis, hepatitis, inflammatory disease, diabetes and other disease. The Antinociceptive activity of the aqueous extract of Terminalia catappa leaves was studied using the tail flick method, glacial acetic acid induced writhing and the hot plate test in albino rats. The aqueous extract (500mg/kg) produced a significant (p<0.01) dose-dependent inhibition of abdominal writhing in rat. The extract of Terminalia catappa (500 mg/kg) showed significant (p<0.05) dose depend increase in tail flick lantency in rat and the result of the hot plate test showed a dose – related and time dependant significant (p<0.01) increase in pain threshold in rat 15 min after treatment at all the doses used in the study. The result indicates that the aqueous extract of Terminalla catappa leaves posseses analgesic activity which may mediated through both central and peripheral mechanism.

Author(s): Saurabh Arjariya, Nitin Nema, Swati Tiwari, Ritu Dubey

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