Fresh leaves of Erigeron floribundus were obtained and its ethanolic extract assessed for antimicrobial, antioxidant free radical scavenging activity as well as phytochemical constituents. Haemolytic activities were also screened to known whether the extract will lyse the blood agar used. Six pathogenic bacteria; the gram positive; Bacillus cereus, Clostridium species, Staphlococcus aureus, and the gram negative: Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli were screened for susceptibilities to the antimicrobial activity of the leaf extract. Five fungi, Yeast, Penicillium sp, Aspergillus niger, Aspergillus flavus and Aspergillus fumigatus were also screened for antifungal properties of the extract. The result indicated that the plant extract showed antimicrobial action but to varying the degree. The extract was screened for its antioxidant property and free radical scavenging capacity. The result indicated that it has high activity in reducing iron chloride solution and it also has high activities in (DPPH) radicals scavenging test. The phytochemical screening of the extracts showed some bioactive ingredient of pharmacological importance like Tannin, Cardiaglycosides and Saponin. Haemolytic assay of the extract showed that it is able to lyse blood cells.