Antidiabetic effect of Anacyclus valentinus L. aqueous extract in normoglycemic and streptozotocin induced-diabetic rats

In Algeria, number of plant species is used to heal diabetes mellitus. The Saharan population of Algeria use Anacyclus valentinus L. called "Gartoufa" against several diseases. The objective of this study is to evaluate the effect of the aerial crude aqueous extract (CAE) part of this plant on diabetes induced in Wistar rats by streptozotocin. The extract was prepared macerating the plant powder in water during 24h, filtrating it and then drying it at 50°C. CAE is rich with tannins, saponins, flavonoids, cardiac glycosides, coumarines, alkaloids, mucilage, amino acids, sugars (46.4%), ash (24.66%) and proteins (11.37%). At 300mg/kg CAE decreased significantly fast hyperglycemia on diabetic treated rats and restored the loss of body weight caused by streptozotocin. Anacyclus valentinus L. is endowed with a significant antidiabetic activity. Further studies are needed to determine compounds responsible of discovered effects and to understand its mechanism.

Author(s): Aicha Lassouani Tadjeddine, Nadia Kambouche, Houria Medjdoub, Boumediène Meddah, Amadou Dicko, Salima. Saidi, Aicha Derdour

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