The anti-arthritic potential of Crateva religiosa hook & frost belonging to family Capparidaceae were evaluated by taking complete Freund’s adjuvant (CFA) induced model. Arthritis was induced by injecting 0.1ml of complete Freund’s adjuvant below the plantar aponeurosis of the right hind paw. Treatment with the extracts and standard started on the day of induction of CFA and continue up to 28 days. In this study both the alcoholic and aqueous extracts significantly (p<0.01) decrease the paw edema on 28th day. They also significantly rectified the deranged hematological parameters and biochemical parameters which is observed from the studies.the alcoholic extracts found to show more effect than aquous extracts in the terms of % of inhibition. The study gives a scientific rational to the use of this plant in arthritis and related conditions.