Agomelatine as a means of Effective Therapy of Anhedonic Endogenous Depressions

To date depressions, to the optional attributes of which anhedonic manifestations belong, becomes more frequent as for the prevalence of mental pathology. According to WHO projections for 2020, diagnosis of depressions as to their frequency will come to the fore, being accompanied by negative consequences in the form of impairment of social functioning of patients and the growing economic costs of society to ensure them. This determines the actuality of studies directed at the development of measures of rising social adaptation of patients with depression, improvement of the quality of life, also by means of optimization of therapeutic approaches and the search for pathogenetically grounded methods of treatment. During the search for “ideal” antidepressive drugs since the 50-ies of XX century their goal-directed synthesis was carried out, associated with the concept of participation of biogenic amines (noradrenaline and serotonin) and their metabolites in the pathogenesis of endogenous depressions.

Author(s): Liliya Abramova and Panteleyeva

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