The paradigm of diagnosis, treatment and follow-up of the patients´ with HIV disease has changed. If in its beginning death was certain, now with the development of Highly Active Antiretroviral Therapy (HAART) it is a chronic disease like Diabetes Mellitus (DM) or Arterial Hypertension (AH). With these changes, patients became older and with more morbidity, some associated with the infection and persistent inflammation, some with the therapy and another group has emerged-HANA (HIV nonassociated AIDS conditions), affecting all organs and systems. The approach of these patients includes a multidisciplinary team. The is no manuscript regarding to this theme in the Portuguese reality.