A review on methodology and application of supercritical fluid technology in pharmaceutical industry

When the critical temperature and pressure of a fluid is crossed it exhibits mixed properties of gases and liquid, and at this state is called Supercritical fluid, while technique utilizing these fluids, is called Supercritical fluid technology. Supercritical fluids have good solvent power and transport capability due to their low viscosity and high diffusivity, which can be manipulated with slight variation in the temperature and pressure. Such properties of the supercritical fluid are utilized in extraction of the drugs, in analytical techniques, in chemical reactions to enhance selectivity, morphology of the particles and also in the development of the drug delivery systems. In this article, we have discussed about the properties of the supercritical fluids along with different variants of the technique and the applications in the pharmaceutical industry.

Author(s): Lovenish Bhardwaj, Pramod Kumar Sharma, Sharad Visht, Vipin Kumar Garg, Nitin Kumar

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