Drinking water is being declined rapidly due to excessive industrialization that leads to the detrimental effects on the quality of water in different cities of Punjab, Pakistan after taking into account the chemical properties and the incidence of heavy metals and microbes. About 80% of the population of Pakistan is oppressed to consume unclean and contaminated drinking water due to shortage of clean water reservoirs. Among different contaminants arsenic serves as a greater contaminant due to its excessive quantity in different sources of water. However the normal level of arsenic should be 0.010 mg/L. Due to its high mobility and speciation it causes arsenicosis disease. The paper also critically reviews the arsenic led human health risks, its uptake, metabolism, and toxicity mechanisms. It focus on drinking water quality in different cities of Punjab, sources of contamination, public health situation, and effects of hazardous drinking water on humans. A number of studies reported and stated arsenic concentrations in Gujranwala (0.94 mg/L), Lahore (179 mg/L), Mailsi (0.39 mg/L), Multan (1000 mg/L), Muzaffargarh (400 mg/L), Sehwan (60.2 mg/L), and Tharparker (0.002 mg/L).