A facile synthesis, spectral characterization and antimicrobial activity of novel dialkylheteroaryl phosphonates

Synthesis of a series of novel dialkylheteroaryl phosphonates (3a-l) was accomplished via Michaelis-Arbuzov rearrangement in high yields (70-80%) by the reaction of various heteroaryl halides (1) with trialkyl phosphite (2) at 50-55^oC in dry tetrahydrofuran (THF) under N₂ atmosphere by using CeCl₃.7H₂O as a catalyst. The structures of the title compounds were established by elemental analyses and spectral data (IR, ¹H, ¹³C and ³¹P NMR and LCMS). All the titled compounds (3a-l) showed promising antimicrobial activity

Author(s): Sampath Chinnam, Kotaiah Yalagala, Hari Krishna Nallapaneni, Naga Raju Chamarthi, Anjaneyulu Ediga and Venkata Rao Chunduri

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