A cost effective one-pot racemization process of 3-(Carbamoylmethyl)-5-
methylhexanoic acid: A Pregabalin Intermediate

K. Suneel Kumar; K. Tatendra Reddy; G. Jagan Mohan Reddy; G. Omprakash; P K Dubey

Abstract

A cost effective one-pot racemization process of 3-(Carbamoylmethyl)-5- methylhexanoic acid: A Pregabalin Intermediate

This paper describes a simple, cost-effective and one pot process for racemization of undesired (S)-3-(carbamoylmethyl)-5-methylhexanoic acid, which produced during the resolution step. The unwanted S-enantiomer was converted into the symmetrical glutarimide derivative in the presence of a catalytic amount of DMAP or pyridine in refluxing toluene followed by hydrolysis with an alkali.

Author(s): K. Suneel Kumar, K. Tatendra Reddy, G. Jagan Mohan Reddy, G. Omprakash, P K Dubey

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