A Comparative Study on Evaluation of In vitro Cytotoxic Activity of Ipomoea pes-caprae and Murraya koenigii

The purpose of the research is to find out the comparative cytotoxic potentials of Ipomoea Pes-Caprae and Murraya koenigii fractions (crude methanol, Pet ether, Chloroform) by using brine shrimp mortality assay. These two plant extracts were tested at concentration 400, 200, 100, 50, 25, 12.5, 7.25, 3.125 µg/ml. The extracts of both plants showed remarkable cytotoxic activity. Following, the ascertainment of LC50 values of the extracts (crude, Chloroform, pet ether) the extracts of Ipomoea Pes-Caprae (1.649,5.691, 1.583 µg/ml) and Murraya koenigii( 4.365, 10, 5.370 µg/ml) were respectively compared to a reference drug vincristin sulphate with LC50 0.839 µg/ml. Ipomoea Pes-Caprae was determined as more cytotoxic than Murraya koenigii. Where chloroform extract of Murraya koenigii showed low cytotoxicity than all the extract of Ipomoea Pes-Caprae.

Author(s): Mohammad Mobarak Hossain, Mahadi Hassan, Arif Istiaq, Rumpa Bhowmic and Sayed Koushik Ahamed

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