A case of Donovanosis is observed. While observing this case, initially it was suspected with verrucous type. Clinically identified as ulcer over right labium majus with pain and itching over the lesions. On examination by Obstetrician, single granulomatous ulcer without induration identified. No observation of leukoplakia and tissue smear for the demonstration of CBG showed negative. The treatment started with 100mg doxycycline twice a day for 10 days, where the ulcer is not healed but the morphology of the lesion changed. After referring to Surgery department, it was suspected to squamous cell carcinoma where the excisional biopsy also confirmed the same. Later right radical hemivulvuctomy done.