Abstract
Largazole as a Promising Treatment for Angiogenic Diseases
Largazole is a macro cyclic depsipeptide, which is isolated from the marine cyanobacterium Symploca sp. Hydrolysis of Largazole leads to the production of Largazole thiol, a highly selective class I histone deacetylase (HDAC) inhibitor and an anti-proliferation agent. This review highlights the current understanding of Largazole in various vascular complications and its mechanism of action and discusses the challenges and future directions of Largazole-based therapeutics.
Author(s): Yuet Ping Kwan, Xiaomeng Wang
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Citations : 55
Journal of Biomedical Science & Applications received 55 citations as per Google Scholar report
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