Complexation Behavior of a Proton Pump Inhibitor with Bivalent Metal Ions

Benzimidazoles act as good ligand to transition metal ions and they exhibit several coordination modes. The synthesis of hetero-chelates of the type ML2.2H2O has been reported here.The metal complex of Co(II) and Ni(II) Complexes have been synthesized with 6-(difluoromethoxy)-2-[(3,4- dimethoxypyridin-2-yl)methylsulfinyl]-1H-benzo[d]imidazole (Pantoprazole). Pantoprazole is a proton pump inhibitor (PPI) drug that inhibits gastric acid secretion. Proton pump inhibitors (or PPI) are a group of drugs whose main action is a pronounced and long-lasting reduction of gastric acid production. Conductometric titrations have suggested metal-ligand ratio of 1:2 for both Co(II) and Ni(II) complexes. The ligand behaves as a bidentate with N, O donor atoms. Complexes have been synthesized and characterized by elemental analysis, UV-visible and IR spectral studies.

Author(s): Suman Malik and Jaishree Morey

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