Synthesis and Characterization of Benzoxazole Derivatives

In view of the fact that a large number of derivatives of benzoxazole have been found to exhibit a wide variety of pharmacological activities. In the current research work , the title compounds were synthesized from 2-substituted Benzoxazole-5-carbohydrazide(II) on treatment with equivalent quantities of anhydrides afforded 1-[(2-substituted-1,3-benzoxazol-5-yl)carbonyl]- 1,2-dihydropyridazine-3,6-dione(IIIa),of1-[(2-substituted-1,3-benzoxazol-5-yl)carbonyl] tetrahydro pyridazine-3,6-dione(IV) and 2-[(1,3-benzoxazol-5-yl)carbonyl]-2,3- dihydrophthalazine-1,4-dione(V).The identification and characterization of all the synthesized compounds were confirmed by Elemental analysis, melting point, Thin Layer Chromatography, FT-IR,1HNMR and Mass Spectral data

Author(s): Srinivas Katla1 , Pradeep Pothana1, Balaswamy Gubba1, Sarangapani Manda2

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