Cancer is a disease of the genome. Cancer genomics involves the study of the cancer genome, its sequence, and the differential expression of genes between tumor cells and normal cells. This area of study is aimed at understanding the genetics underlying cancer cell proliferation, and the development of the cancer genome in response to mutational pressure provided by the micro environment. Of late, thanks to the next generation sequencing, several advances have been made towards the characterization of mutations and structural alterations associated with a wide variety of cancers. The analysis of cancer genomes has shed light on genetic abnormalities that drive the growth and development of many cancers, this information has improved our understanding of cancer biology, resulting in newer and better diagnostics and interventions. The understanding of cancer genomics might even open doors to personalized medicine in the near future.