Journal of Neurodegenerative Diseases and Disorders

About Journal of Neurodegenerative Diseases and Disorders

Neurodegenerative Diseases and Disorders is an online journal which facilitates the new interventions and discoveries in neurodegenerative diseases and disorders. It covers all areas of neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, amyotropic lateral sclerosis, Huntington’s disease and related neurological and psychiatric disorders.

Neurodegenerative Diseases and Disorders is a bimonthly journal and accepts high-quality papers in the form of either short reports or articles from a broad spectrum of scientific research areas ranging from molecular and cell biology to neuroscience, pharmacology, genetics and clinical sciences.

Journal of Neurodegenerative Diseases is a peer-reviewed, open access journal that publishes original research articles, review articles, and clinical studies related to all aspects of neurodegenerative diseases. To submit manuscript send us an e-mail attachment to the Editorial Office at [email protected] or through online submission at insightjournals

Neurodegenerative diseases

Neurodegenerative diseases are incurable conditions that are result of the progressive degeneration and/or death of nerve cells/ neurons. Neurodegenerative diseases affect many of your body's activities, such as balance, movement, talking, breathing, and heart function. Many of these diseases are genetic but they can also be caused by some medical condition such as alcoholism, a tumor, or a stroke or even by toxins, chemicals, and viruses.

Many neurodegenerative diseases including amyotrophic lateral sclerosis, Parkinson's, Alzheimer's, and Huntington's occur as a result of neurodegenerative processes. Such diseases are incurable, resulting in progressive degeneration and/or death of neuron cells.

Neurological disorders

The term Neurological disorder applies to any condition that is caused by a dysfunction in part of the brain or nervous system, resulting in physical and/or psychological symptoms.Neurological disorders are diseases of the brain, spine and the nerves that connect them. These disorders include epilepsy, Alzheimer disease and dementia, stroke, migraine and other headache disorders, multiple sclerosis, Parkinson's disease, neuroinfections, brain tumours, traumatic disorders of the nervous system due to head trauma, and neurological disorders as a result of malnutrition. Many bacterial, viral, fungal and parasitic infections can affect the nervous system. Neurological symptoms may occur due to the infection itself, or due to an immune response.

Neuronsciences

Neuroscience is the field of studying various scientific disciplines dealing with the structure, development, function, chemistry, pharmacology, pathology, molecular biology of nerves and nervous tissue and especially their relation to behavior and learning.

It is a vast fied consisting of following branches: neurophysiology, neuroanatomy, neuropharmacology, (behavioural, developmental, cognitive, systems, molecular, computational) neuroscience, neurology.

Alzheimer

It is a Neurodegenerative disorder. The symptoms of this disease is it damage the brain results in memory loss,difficulty in remembering information and learning.The symptoms are different according to the individuals and area of brain affected. Alzheimers is the high leading cause of death in the world.Depending on the age and health conditions alzheimers patients can survive 8-15 yrs after symptoms become noticeable.There is no specific cause of Alzheimers but researchers they believe that Environmental factors and genetic factors may induce abnormal process in brain that leads to Alzheimers.

Parkinson

Parkinson's disease is a disorder of the nervous system that affects your movement and mental ability. It develops gradually, shaking in thumb, chin or lip, moments during sleeping,feeling dizzy,low blood pressure. Parkinson's disease can't be cured. In some cases, doctors may suggest medication, Pharmacology treatment and surgery to re certain regions of your brain . anti-Parkinson disease medication treatment is good control of parkinson diesease for 4-5 yrs. Physiothery is also a good treatment to improve your muscle strength.

Huntington's disease

Huntington disease is an inherited disease.Huntington disease causes the degeneration of nerve cells in brain. This leads to functional inabilities and psychiatric disorders. Huntington disease also affects muscle coordination. It is caused by an inherited defect in a single gene. Gene that causes Huntington disease is HIT gene. Symptoms of the disease can vary between individuals and affected members of the same family, but usually progress predictably.

Amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis is also known as motor neurone disease is a specific disease that causes the death of neurons which control voluntary muscles. The disease is progressive, meaning the symptoms get worse over time.

Some also use the term motor neuron disease for a group of conditions of which ALS is the most common. ALS is characterized by stiff muscles, muscle twitching, and gradually worsening weakness due to muscles decreasing in size.This results in difficulty speaking, swallowing, and eventually breathing.

Currently, there is no cure for ALS and no effective treatment to halt, or reverse, the progression of the disease.

Spinocerebellar Degeneration

Spinocerebellar ataxia (SCA), also known as spinocerebellar atrophy or spinocerebellar degeneration, is a progressive, degenerative, genetic disease with multiple types.SCA can affect anyone of any age.

The signs and symptoms may vary by type but are similar, and may include an uncoordinated walk (gait), poor hand coordination, abnormal speech involuntary eye movement, vision problems, difficulty processing, learning, and remembering information.In general, a person with ataxia retains full mental capacity but progressively loses physical control.

There is no known cure for spinocerebellar ataxia (SCA). The best treatment options for SCA vary by type and often depend on the signs and symptoms present in each person.

Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is a rare neuromuscular disorder characterised by loss of motor neurons and progressive muscle wasting, often leading to early death.The disorder is caused by a genetic defect. In this the loss of motor neurons leads to weakness and wasting (atrophy) of muscles used for activities such as crawling, walking, sitting up, and controlling head movement.

In severe cases of spinal muscular atrophy, the muscles used for breathing and swallowing are affected. There are many types of spinal muscular atrophy distinguished by the pattern of features, severity of muscle weakness, and age when the muscle problems begin. By far Nusinersen is the only approved drug to treat spinal muscular.

Creutzfeldt-Jakob disease

Creutzfeldt-Jakob disease is a human prion disease. It is a neurodegenerative disorder with characteristic clinical and diagnostic features. This disease is rapidly progressive and always fatal. Infection with this disease leads to death usually within 1 year of onset of illness.

CJD is a rapidly progressive, invariably fatal neurodegenerative disorder believed to be caused by an abnormal isoform of a cellular glycoprotein known as the prion protein. Early symptoms include memory problems, behavioral changes, poor coordination, and visual disturbances. Later dementia, involuntary movements, blindness, weakness, and coma occur.

About 90% of people die within a year of diagnosis.

Variant Creutzfeldt-Jakob disease

Variant Creutzfeldt-Jakob disease (vCJD) is a rare and fatal human neurodegenerative condition.It is is classified as a Transmissible Spongiform Encephalopathy (TSE) because of its ability to be transmitted and the characteristic spongy degeneration of the brain that it causes.

The consumption of food of bovine origin contaminated with the agent of Bovine Spongiform Encephalopathy (BSE), a disease of cattle, has been strongly linked to the occurrence of vCJD in humans.

Early in the illness, patients usually experience psychiatric or sensory symptoms, which most commonly take the form of depression, anxiety, unusual persistent and painful sensory symptoms.

Neurological signs, including unsteadiness, difficulty in walking and involuntary movements, develop as the illness progresses and, by the time of death, patients become completely immobile and mute.

Gerstmann-Straussler-Scheinker disease

Gerstmann-Straussler-Scheinker disease (GSS) is a type of prion disease. It is a very rare, usually familial, fatal neurodegenerative disease that affects patients from 20 to 60 years in age. This extremely rare disease is classified with the transmissible spongiform encephalopathies (TSE) due to the causative role played by PRNP, the human prion protein. It is caused by changes (mutations) in the PRNP gene and inheritance is autosomal dominant.

The main feature of GSS is a progressive degeneration of the cerebellum as well as different degrees of dementia. Signs and symptoms generally develop between ages 35 and 50 years and may include weakness in the legs, poor reflexes, abnormal sensations, progressive ataxia, cognitive dysfunction, slurred speech, and spasticity.

On average, people affected by GSS survive approximately 60 months (range 2 to 10 years) following diagnosis. It is caused by changes (mutations) in the PRNP gene and inheritance is autosomal dominant.There is no cure for GSS, nor is there any known treatment to slow the progression of the disease.

Journal Highlights

  • Neurodegenerative diseases
  • Neurological disorders
  • Neuronsciences
  • Alzheimer
  • Parkinson
  • Huntington's disease
  • Amyotrophic lateral sclerosis
  • Spinocerebellar Degeneration
  • Spinal Muscular Atrophy
  • Creutzfeldt-Jakob disease
  • Variant Creutzfeldt-Jakob disease
  • Gerstmann-Straussler-Scheinker disease
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