Journal of Molecular and Cellular Biochemistry is a scholarly periodical that explores the latest research advancements in the field of Biochemistry of cells and Molecules with great precision. This scholarly journal thus focuses on a wide range of topics within this field by including research on Molecular cloning, Polymerase chain reaction (PCR), Gel electrophoresis, Microarrays, transcription, translation, bioinformatics, phylogenetics, cytoskeletal function, membrane transport, receptor mechanism, immune response, secretory processes, Biomolecules, and Metabolism.
Authors can Submit manuscript as an email attachment to [email protected] (or) online at www.imedpub.com/submissions/molecular-cellular-biochemistry.html
Transcription refers to the chemical synthesis of RNA from a DNA template. Transcription is the first stage of the expression of genes into proteins. In transcription, a mRNA (messenger RNA) intermediate is transcribed from one of the strands of the DNA molecule. The RNA is called messenger RNA because it carries the 'message' or genetic information from the DNA to the ribosomes, where the genetic information is used to make proteins. Transcription may be broken into five stages: pre-initiation, initiation, promoter clearance, elongation, and termination.
Transcriptomics: Open Acess, Journal of Proteomics & Bioinformatics, Enzyme Engineering, Journal of Data Mining in Genomics & Proteomics, Journal of Bioprocessing & Biotechniques, Protein Engineering Design and Selection, Journal of Tissue Science & Engineering,
Molecular cloning is used to assemble recombinant DNA molecules and do their replication within host organisms. The word cloning here means the replication of one molecule to large number of cells with identical DNA molecules. Molecular cloning usually involves DNA sequences from two different organisms: one of the species is source of the DNA to be cloned, and other will act as a living host for replication of the recombinant DNA. Applications of molecular cloning includes- Genome organization and gene expression, Production of recombinant proteins, Transgenic organisms and Gene therapy.
Molecular Cloning and Related Journals:
Journal of Glycobiology, Journal of Tissue Science & Engineering, Journal of Molecular Biomarkers & Diagnosis, Journal of Proteomics & Bioinformatics, Journal of Stem Cell Research & Therapy, Electronic Journal of Biology, Biology and Medicine
Polymerase chain reaction (PCR) in molecular biology is used to amplify a single copy or a few copies of a DNA segment across several orders of magnitude, it can generate thousands to millions copies of a particular DNA sequence. PCR amplifies a specific region of a DNA strand called the DNA target. Most PCR methods amplify DNA fragments of between 0.1 and 10 kilo base pairs (kbp), The amount of amplified product is determined by the substrates in the reaction. Applications of polymer Chain Reaction- Selective DNA isolation, Amplification and quantification of DNA, genetic testing, tissue typing, leukemia, lymphomas, human immunodeficiency virus, tuberculosis and genetic fingerprinting.
Applied Microbiology: Open Access, Journal of Molecular Biomarkers & Diagnosis, Journal of Medical Microbiology & Diagnosis, Journal of Molecular and Genetic Medicine, Journal of Microbial & Biochemical Technology, Cloning & Transgenesis.
Gel electrophoresis is a laboratory method to separate mixtures of DNA, RNA, or proteins on the basis of their molecular size and charge. It is used in clinical chemistry to separate proteins by charge and/or size (IEF agarose, essentially size independent). Types of gels in gel electrophoresis are- Agarose, Polyacrylamide, Starch. Applications of gel electrophoresis are restriction mapping, genetic diagnosis or genetic fingerprinting, forensics, molecular biology, genetics, microbiology and biochemistry etc.
Journal of Clinical & Experimental Ophthalmology, Advanced Techniques in Biology & Medicine, Journal of Chromatography & Separation Techniques, Journal of Data Mining in Genomics & Proteomics, Journal of Biotechnology & Biomaterials.
A DNA microarray, commonly known as DNA chip or biochip. is a collection of microscopic DNA spots which are attached to a solid surface. DNA microarrays measures the expression levels of large numbers of genes simultaneously or to genotype multiple regions of a genome. The principle behind microarrays is hybridization between two DNA strands, the property of complementary nucleic acid sequences to specifically pair with each other by forming hydrogen bonds between complementary nucleotide base pairs. DNA microarrays are used to detect DNA (as in comparative genomic hybridization), or detect RNA (mostly as cDNA after reverse transcription) that may or may not be translated into proteins. It has applications in Gene expression profiling, Comparative genomic hybridization, Chromatin immunoprecipitation on Chip, Fusion genes microarray and Double-stranded B-DNA microarrays etc.
Journal of Proteomics & Bioinformatics, Journal of Food: Microbiology, Safety & Hygiene, Journal of Biotechnology & Biomaterials, Drug Designing: Open Access, Journal of Next Generation Sequencing & Applications, Biochemistry & Physiology: Open Access.
Biomolecules are defined as the molecules that occur naturally in living organisms. Biomolecules include molecules like proteins, carbohydrates, lipids and nucleic acids. It also includes small molecules like primary and secondary metabolites and natural products. Proteins are responsible for many enzymatic functions in the cell and play an important structural role. Biomolecules are usually endogenous and also exogenous and mostly in form of organic compounds, just the four elements—oxygen, carbon, hydrogen, and nitrogen—make up 96% of the human body's mass. It is used in Bio-immobilization and bio-conjugation, Polymerase chain reaction, Enzyme-linked immune sorbent assay (ELISA), Bioengineering, Biochemical engineering etc.
Phylogenetics deals with study of evolutionary relationships among biological entities - often species, individuals or genes. Phylogenetics is important because it enhances our understanding of how genes, genomes, species (and molecular sequences more generally) evolve. With the help of phylogenetics, we not only learn how the sequences came to be the way they are today, but also about the general principles that enable us to forecast how they are going to change in the future. Applications of phylogenetics are in forensics, pathogen surveillance, conservation and bioinformatics.
Immune response can be defined as a response of the body to an antigen that occurs when lymphocytes identify the foreign antigenic molecule and induce the antibodies formation. Lymphocytes capable of reacting with it and rendering it harmless —called also immune reaction. Overall, the immune system is comprised of various parts that performs various functions, from recognizing and acting against the invaders, or antigens, to working throughout the body to prevent infection, and finally to remember those antigens from previous attacks in order to put up an even stronger fight in future instances.
Journal of Allergy & Therapy, Journal of AIDS & Clinical Research, Immunome Research, Journal of Clinical & Cellular Immunology, European Journal of Immunology, Journal of Leukocyte Biology, Journal of Autoimmunity and journal of International Immunology.
Membrane transport regulates the passage of solutes such as ions and small molecules through biological membranes, consisting lipid bilayers that contain proteins embedded in them. Selective membrane permeability - a characteristic of biological membranes which allows them to separate substances of distinct chemical nature and allow certain specific desired substance to pass. The function of the selective membrane permeability is to regulate the transport through membrane. Membrane Transport can be through, Passive diffusion, Active and co-transport, Pumps.
The cytoskeleton is a network of fibers these fibres form the "infrastructure" of eukaryotic cells, prokaryotic cells, and archaeans. Cytoskeleton Function- The cytoskeleton extends throughout the cell's cytoplasm and provides a number of important functions. It helps the cell to maintain its shape and gives support to the cell to make it stable. It helps the cellular organelles to be held in place. It assists in the formation of vacuoles. The cytoskeleton does not have a static structure, but is able to disassemble and reassemble its parts so that internal and overall cell mobility can be achieved.
Single Cell Biology, Journal of Clinical & Cellular Immunology, Journal of Stem Cell Research & Therapy, Cellular and Molecular Biology, Journal of Cell Science & Therapy, Cell & Developmental Biology,.
Author(s): Charitha Gangadharan, Nataraj KS, Snehali Majumder and Alben Sigamani *
Minimal residual disease (MRD) represents the residual disease diagnosed following therapy for acute lymphoblastic leukemia (ALL) by molecular methods of multiparameter flow cytometry or quantit ... Read More