stroke-cns-2018-posters-abstracts

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I n t e r n a t i o n a l C o n f e r e n c e o n

Neurological Disorders,

Stroke and CNS

October 22-23 , 2018

Athens , Greece

Journal of Neurology and Neuroscience

ISSN: 2171-6625

Stroke and CNS 2018

troke is great challenge to human health. Blood brain barrier and nerve regeneration is the key factor for stroke treatment. Wu

Shen Xing Nao Fang (WSXN) is composed of ginseng polygoni multiflori radix and gingko leaf, with the function of promoting

blood circulation to remove blood stasis and awakening brain function has been made into dropping pill available for clinical

stroke.

Breaking the blood-brain barrier and brain targeting

WSXN could reversibly open the blood-brain barrier, increasing the bioavailability of ginseng saponins, distyrene and ginkgolide,

through the blood brain barrier into the brain tissue, to increase the concentration of within the brain tissue as much as 2~10

times. Oral dosage of 40, 80 mg/kg of WSXN for 7 days or 14 days can significantly reduce ischemic infarction area to more than

35% in MCAO and 4 VO cerebral ischemia models of rats, inhibit the neuroinflammation and mortality of the hippocampus CA1

area neurons >60%; and also improve the learning and memory of damaged rats; increase the number of BrdU positive cells in the

ischemic tissue by 300% and promote the nerve regeneration. 0.2~5 µg/ml of WSXN can promote the proliferation and directional

differentiation of neural stem cells, reduce neuronal injury and apoptosis of the neuron induced by hypoxia oxidative stress and

Aß 25-35, whose efficacy index is superior to that of ginkgo biloba extract (EGB761 ®). Oral administration of WSXN for 90 days

showed no obvious liver and kidney toxicity in rats. Clinical volunteers orally taking WSXN pill 0.35 g a time, three times a day,

for 2~6 months, can eliminate sequela hemiplegia and movement disorder of the stroke patients and muscle tremor symptom of

Parkinson's disease, resulting in independent living with effective rate > 80%

Chinese medicine for stroke, breaking through

blood brain barrier and promoting neurogenesis

Wei Jian Bei ,Wei Xu, Yadong Zhu, Jing Zhu, Wenyi Liang,

Caijuan Guo, Yijian Huang, Jiangfeng Yu, Yuping Li and

Jiao Guo

Guangdong Province Research Centre for Chinese Integrative Medicine Against Metabolic Dis-

ease, Guangdong TCM key laboratory against metabolic diseases, Guangdong Pharmaceutical

University, China

J Neurol Neurosci 2018, Volume: 9

DOI: 10.21767/2171-6625-C3-015

Fig 2: Neuroprotection and neuroregenesis of WSXN