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I n t e r n a t i o n a l C o n f e r e n c e o n
Neurological Disorders,
Stroke and CNS
October 22-23 , 2018
Athens , Greece
Journal of Neurology and Neuroscience
ISSN: 2171-6625
Stroke and CNS 2018
W
e previously found that aspirin decreases the risk of cerebral aneurysm rupture in humans. We aim to assess whether a
sex differential exists in the response of human cerebral aneurysms to aspirin and confirm these observations in a mouse
model of cerebral aneurysm. A nested case-control analysis from the international study of unruptured intracranial aneurysms
was performed to assess whether a sex differential exists in the response of human cerebral aneurysms to aspirin. A series of
experiments were subsequently performed in a mouse model of cerebral aneurysms. Aneurysms were induced with hypertension
and elastase injection into mice basal cisterns. We found that aspirin decreased the risk of aneurysm rupture more significantly
in men than in women in the International Study of Unruptured Intracranial Aneurysms. In mice, aspirin and cyclooxygenase-2
inhibitor did not affect cerebral aneurysm formation but significantly decreased the incidence of rupture. The incidence of
rupture was significantly lower in male versus female mice on aspirin. Gene expression analysis from cerebral arteries showed
higher 15-hydroxyprostaglandin dehydrogenase levels in male mice. The rate of cerebral aneurysm rupture was similar in
male mice receiving aspirin and 15-hydroxyprostaglandin dehydrogenase inhibitor compared with females receiving aspirin
and 15-hydroxyprostaglandin dehydrogenase agonist, signaling a reversal of the sex-differential response to aspirin. Aspirin
decreases aneurysm rupture in human and mice, in part through cyclooxygenase-2 pathways. Evidence from animal and human
studies suggests a consistent differential effect by sex. 15-hydroxyprostaglandin dehydrogenase activation in females reduces
the incidence of rupture and eliminates the sex-differential response to aspirin.
david-hasan@uiowa.eduDifferential sex response to aspirin in decreasing
aneurysm ruptures in humans and mice
David M Hasan
University of Iowa Hospitals and Clinics, USA
J Neurol Neurosci 2018, Volume: 9
DOI: 10.21767/2171-6625-C3-015