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Page 34

I n t e r n a t i o n a l C o n f e r e n c e o n

Neurological Disorders,

Stroke and CNS

October 22-23 , 2018

Athens , Greece

Journal of Neurology and Neuroscience

ISSN: 2171-6625

Stroke and CNS 2018

I

ntracerebral hemorrhage (ICH), a detrimental disease, is associated with one month fatality in 40% of patients and worst

neurological outcome among survivors. In the past several years, emerging evidence suggests that inflammatory and excitotoxic

mechanisms are in the core of the pathophysiological processes, leading to neurological deterioration and secondary brain

injury after ICH, thus being tied up to the patient’s outcome. Following ICH, tumor necrosis factor-α (TNF-α) signalling exerts an

acute detrimental role, being also argued as the main driver for increase in the blood brain barrier permeability and formation of

the perihematomal edema. Elevated perihematomal glutamateinduced excitotoxicity have also been associated with the blood

brain barrier disruption and neuronal death, severely affecting patient prognosis. In this lecture, we discuss the results from our

working group which support the idea that peripheral TNF-α and glutamate levels can reflect CNS inflammation and excitotoxicity

following ICH, as well as their utility as biomarkers for prognostication and clinical decision making between conservative or

surgical treatment in patients with ICH.

vladimirrendevski@yahoo.com

Prognostic values of peripheral glutamate and

TNF-

α

levels in patients with intracerebral

haemorrhage

Vladimir Rendevski, Boris Aleksovski and Mihajlovska

Rendevska

Saints Cyril and Methodius University of Skopje, Macedonia

J Neurol Neurosci 2018, Volume: 9

DOI: 10.21767/2171-6625-C3-015