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I n t e r n a t i o n a l C o n f e r e n c e o n
Neurological Disorders,
Stroke and CNS
October 22-23 , 2018
Athens , Greece
Journal of Neurology and Neuroscience
ISSN: 2171-6625
Stroke and CNS 2018
I
ntracerebral hemorrhage (ICH), a detrimental disease, is associated with one month fatality in 40% of patients and worst
neurological outcome among survivors. In the past several years, emerging evidence suggests that inflammatory and excitotoxic
mechanisms are in the core of the pathophysiological processes, leading to neurological deterioration and secondary brain
injury after ICH, thus being tied up to the patient’s outcome. Following ICH, tumor necrosis factor-α (TNF-α) signalling exerts an
acute detrimental role, being also argued as the main driver for increase in the blood brain barrier permeability and formation of
the perihematomal edema. Elevated perihematomal glutamateinduced excitotoxicity have also been associated with the blood
brain barrier disruption and neuronal death, severely affecting patient prognosis. In this lecture, we discuss the results from our
working group which support the idea that peripheral TNF-α and glutamate levels can reflect CNS inflammation and excitotoxicity
following ICH, as well as their utility as biomarkers for prognostication and clinical decision making between conservative or
surgical treatment in patients with ICH.
vladimirrendevski@yahoo.comPrognostic values of peripheral glutamate and
TNF-
α
levels in patients with intracerebral
haemorrhage
Vladimir Rendevski, Boris Aleksovski and Mihajlovska
Rendevska
Saints Cyril and Methodius University of Skopje, Macedonia
J Neurol Neurosci 2018, Volume: 9
DOI: 10.21767/2171-6625-C3-015