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Imaginary Views of Challenging Trends in Medicine and their Associated Challenges in Pharmaceutical Industry

Ahed J Alkhatib*


Department of Legal Medicine, Toxicology of Forensic Medicine, School of Medicine, Jordan University of Science and Technology, Jordan

*Corresponding Author:
Ahed J Alkhatib
Department of Legal Medicine
Toxicology of Forensic Medicine
School of Medicine, Jordan University of Science and Technology
[email protected]

Received date: Septemeber 19, 2017; Accepted date: October 03, 2017; Published date: October 10, 2017

Citation: Alkhatib AJ (2017) Imaginary Views of Challenging Trends in Medicine and their Associated Challenges in Pharmaceutical Industry. J Pharmacol Rev Rep Vol.1 No.1:1

Visit for more related articles at Journal of Pharmacological Reviews and Reports

Medicine has recently witnessed revolutionary phases and the term personalized medicine has emerged implying targeting the individual patient rather than a group of patients [1].

Personalized medicine implies the appropriate choice of treatment for an individual. The criteria of this choice involve age, gender, body mass index (BMI), ethnicity, diet and environment [2].

Another term, precision medicine has been introduced following personalized medicine. Precision medicine concerns with treatment choice and designing especial products for certain individuals [3].

The study of Turck [4] showed that the cost of oncology drug is increasing, and the increased cost of personalized medicine is a new trend.

In their conference study, Victor et al. [5] indicated that there is a lack of studies about new drug discovery/development on central nervous system (CNS) cancers. The reasons include several considerations such as economic factors and other reasons relating to pharmaceutical risk assessments, and regulatory limitations.

The treatment of hepatitis C virus (HCV) depends on genetic polymorphism and the concept of personalized medicine is applied [6,7]. It has been estimated that about half of HCV patients do not respond to therapy according to such considerations and no predominant genotype has been identified universally [7,8].

The treatment of HCV is highly costing and makes burden on the economy of developing country, particularly when it is associated with HIV [8].

The concepts of epigenetics bear the hope for developing new therapeutic strategies that may develop kinetic models to predict the outcome of diseases including HCV. It has been shown that the epigenetic control for expression of genes is a basic concept in carcinogenesis. Furthermore, hepatocellular carcinoma has involved certain molecular mechanisms that make a complicated picture for genetic and epigenetic factors. There are four main mechanisms in the field of epigenetics including methylation of DNA, histone proteins, chromatin remodeling, and noncoding RNAs [9].

We have found that the expression of certain proteins such as p53 and WT1 can predict the progression of acute myeloid leukemia (AML). Furthermore, the model we obtained may give us the ability to intervene in patients with this disease. We are planning to publish our findings as soon as possible.

Returning back to environment is helpful and may uncover new therapeutic properties. We have recently published an article in which Alhagi graecorum was effective in the treatment of Herpes Zoster (Shingles) [10].

In their study, Toporkiewicz et al. [11] highlighted the issues related to the introduction of systemic drugs in addition to approaching their targets. Targeting approaches bear the ideas of enhancing drug delivery through lowering toxicity associated with such drugs and reducing their side effects. Targeting depends on using the properties of cell- surface affinity directly or as being drug carriers. The appropriate selection of the right ligand includes its binding affinity. In this context, it is important to put focus on some ligands including monoclonal antibodies, antibody derivatives, peptides, and small targeting molecules.

In a recent study, we reported that estrogen and its receptors have therapeutic potential in a wide spectrum of diseases including infectious diseases, autoimmune diseases and cancers [12].

In conclusion, there must be creative solutions in pharmaceutical industry to cope with emerging trends in medicine. Critical challenges such as economic conditions must be searched for alternatives. Research in pharmacy has to be more activated based on herbal and other alternative solutions.


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