Achyranthes aspera is well-known plant in Indian traditional medicines, strongly recommanded for healing properties of skin diseases by some rural communities. In present investigation the leaves part of this plant is evaluated for wound healing activity on various models including excision, incision and dead space and histopathological models to prove it scientifically. The methanolic extract of leaves of Achyranthes aspera was examined for wound healing activity in the form of ointment on albino mice. The extract showed considerable response in all the above said wound models as comparable to those of a standard drug Povidine iodine in terms of wound contracting ability, wound closure time, tensile strength and dry granuloma weight. Histological analysis was also consistent with the proposal that Achyranthes aspera leaves extract exhibits significant wound healing activity.