Calciphylaxis is a rare complication often seen in patients with End Stage Renal Disease (ESRD). We report a case of a female patient with chronic kidney disease who developed calciphylaxis with secondary hyperparathyroidism. The patient failed standard medical treatment and did not want to proceed with surgery. Sodium Thiosulfate (STS) was used to treat bilateral lower extremity ulcers on a regimen of three times per week over 9 weeks. The ulcers improved significantly and were completely healed at the end of the treatment cycle. There has been no recurrence of ulcers in the past 18 months since treatment. We present this case to highlight the importance of STS treatment for calciphylaxis induced lower extremity ulcers which may prevent the need to proceed with more invasive techniques such as surgery, wound debridements and skin grafting or flaps.