In this paper, we study anti-microbial activity of ten kinds of C3,6-dichloroacetyl phenyl-thiosemicarbazone-chitosan derivatives against four species of bacteria and four fungi at different concentrations. And the mechanism of antimicrobial was discussed. The results showed that the antimicrobial activities of all derivatives were stronger than that of Chitosan. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the derivatives against Escherichia coli were 7.40 μg mL-1 and 29.16 μg mL-1 respectively. All of the derivatives had a definite antifungal effect on fungi in the concentration range of 0.05 mg·mL-1 to 2 mg·mL-1, with a maximum inhibition index of 100%. The results showed that the antibacterial abilities of the derivatives have potential value in the field of new pesticide development.
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