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Synthesis, Characterization, DNA Interaction and Anticancer Activity of Organotin(IV) Complexes with Sodium 3-(1H-indol-3-yl) propanoate

Six organotin(IV) complexes have been synthesized by refluxing sodium salt of 3-(1H-indol-3-yl) propanoic acid with di- and triorganotin chlorides in 1:1 and 2:1 molar ratios, respectively. These complexes have been characterized by elemental analysis, IR, 1H, 13C and 119Sn NMR spectroscopies. DNA binding studies were performed by viscometric measurements and UV-visible spectroscopy. Both techniques showed an intercalation mode of interaction. The cytotoxic activity of ligand salt and organotin(IV) complexes 1-6 was tested against human ovarian cell line A2780. Results of bioassay revealed that organotin derivatives were more active than anticancer drug cis-platin. Triorganotin(IV) compounds are found more potent for their cytotoxic activity as compared to corresponding diorganotin(IV) complexes.

Author(s): Shaheen F, Ali S, Shahzadi S

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