Synthesis, characterization and antibacterial activity of some oxadiazole substituted triazole derivative

The increasing clinical importance of drug resistance of fungal and bacteria pathogen has lent additional urgency to microbial research and new antimicrobial compound development . For this purpose a series of N-(substituted aryl -1,3,4-oxadiazole -2 yl) methyl-N-(4H-1,2,4 – triazol-4 yl) benzamide derivative was synthesized by condensation of 4amino triazole and benzoyl chloride . The treatment of benzoyl derivative of 4-amino Triazole with sodium ethoxide and ethylchloro acetate produce ester derivative of Triazole (2). Subsequently compound (2) was converted to hydrazide by (3) the treatment with hydrazine hydrate after esterification. More over the reaction of compound (3) with aromatic acid in phosphorus oxychloride afforded N- (substituted aryl -1,3,4-oxadiazole -2 yl) methyl-N-(4H-1,2,4 –triazol-4 yl) benzamide 4(a-h). The identification and characterization of the synthesized compounds were carried out by Elemental analysis, melting point,Thin Layer Chromatography, FT-IR, NMR data to ascertain that all synthesized compounds were of different chemical nature than the respective parent compound. Antimicrobial and antifungal activities of the final compounds have been evaluated and all the compounds have shown significant inhibition of bacterial and fungal growth.

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