Synthesis, Antibacterial, Molecular Docking, DNA Binding and Photonuclease Activity of Quinoline Isoxazoles

Isoxazole nuclease is a constituent of many bioactive heterocyclic compounds that are of wide interest because of their diverse biological and clinical applications. The antibacterial, In-silico molecular docking, DNA binding, thermal denaturation, viscosity measurements and photonuclease activity of newly synthesized quinoline isoxazole containing SH/SeH were described. Antibacterial potential of these compounds screened against a wide range of Gram-positive and Gram-negative bacteria showed significant zone of inhibition and MIC with standard drug ciproflaxin were studied. In molecular docking second orientation exibit binding, docking energy with inhibition constant. The absorbance plot showed active interaction of parent isoxazole derivative with CT DNA as efficient DNA intercalator (K_b = 3.8×10⁵ M^-1). The viscosity measurements and thermal denaturation studies afford the positive results in intercalation with DNA. The light induced DNA damage is pragmatic in the absence of various “inhibitors” showed on photo cleavage studies at 360 nm.

Author(s): Sharath N, Halehatty S. Bhojya Naik, Vinay Kumar B and Joy Hoskeri

Abstract | PDF

Share This Article