Synthesis and Characterization of some 5H-dibenzo (b,f)azepine-5- carboxamido-4’-aryl-3’-aryl piperazine-2’-azetidinone derivatives

The synthesis of 5H-dibenzo(b,f)azepine-5-carboxylic acid [3-chloro-2-(substituted phenyl)-4-oxo-azetidin-1-yl]- amide (2a-d) was achieved by the reaction of (1a-d) with chloroacetyl chloride in presence of triethylamine. Three substituted aryl piperazine derivatives (R1-3) were prepared and they were reacted with (2a-d) to give 5Hdibenzo( b,f) azepine-5-carboxamido-4’-aryl-3’-aryl piperazine-2’-azetidinone (3a-l). The products have been characterized by elemental analysis, IR, 1H NMR, 13C-NMR and mass spectral studies

Author(s): Vimal Patel, Nilay D Bhatt, Pravin M. Patel, Pralav Bhatt and H D Joshi

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