Synthesis and biological studies of triazole-azetidinone containing compounds

3-(4H-1,2,4-triazol-3-ylthio)-N-arylidene propane hydrazide (2a-f) was prepared good yields by reaction between 3- (4H-1,2,4-triazol-3-ylthio)propane hydrazide (1) with aromatic aldehydes. Cyclo condensation of compounds (4a-f) with chloroacetyl chloride yields 3-(4H-1,2,4-triazol-3-ylthio)-N-(3-chloro-2-oxo-4-substituted phenylazetidin-1- yl)propanamide (3a-f). The structures of these compounds were established on the basis of analytical and spectral data. All the newly synthesized compounds were evaluated for their antibacterial and antifungal activities.

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