Synthesis and biological studies of novel thiazolidinones

4-(furan-2-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide (1) undergoes facile condensation with aromatic aldehydes (2a-h) to afford corresponding N-arylidene-4-(furan-2-yl)-6-methyl-2-oxo-1,2,3,4- tetrahydropyrimidine-5-carbohydrazide (3a-h) in good yields. Cyclocondensation of compounds (3a-h) with thioglycolic acid yields 4-(furan-2-yl)-6-methyl-2-oxo-N-(4-oxo-2-arylthiazolidin-3-yl)-1,2,3,4-tetrahydro pyrimidine-5-carboxamide (4a-h). The structures of these compounds were established on the basis of analytical and spectral data. All newly synthesized compounds were evaluated for their antibacterial and antifungal activities.

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