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Abstract

Synthesis and biological studies of N-(3-chloro-2-aryl-4-oxoazetidin-1-yl)-2-(5-((naphthalen-1-yloxy)methyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl)acetamide

2-(5-((Naphthalen-1-yloxy)methyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl) aceto hydrazide (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding N'-arylene-2-(5-((naphthalen-1- yloxy)methyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl)acetohydrazide (2a-h) in good yield. Cyclocondensation of compounds (2a-h) with chloro acetyl chloride yields N-(3-chloro-2-aryl-4-oxoazetidin-1-yl)-2-(5- ((naphthalen-1-yloxy)methyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl)acetamide (3a-h). The structures of these compounds were established on the basis of analytical and spectral data. The newly synthesized compounds were evaluated for their antibacterial and antifungal activities.


Author(s): Ashok Prasad,K. S. Nimavat and K. B. Vyas

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Abstracted/Indexed in

  • Chemical Abstracts Service (CAS)
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • Directory of Research Journal Indexing (DRJI)
  • Proquest Summons
  • EBSCO Host
  • International Committee of Medical Journal Editors (ICMJE)
  • Serials Union Catalogue (SUNCAT)
  • Geneva Foundation for Medical Education and Research
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