Synthesis and antioxidant activity of Metal (II) complexes of isocoumarin derivatives

The copper (II), cobalt (II) complexes of 4-alkyl-isocoumarin-3-carboxylic acid,4-alkyl-3-aroyl-isocoumarin has been synthesized and characterized by elemental analysis, thermal analysis followed by IR Spectra. Mononuclear structure for the complexes with isocoumarin derivatives and two water ligands per metal (II) ion is presented with the help of possible data. A study of antioxidant activity of cobalt and copper complexes of isocoumarin derivatives are reported here. Finally the metal ligand binding mode in the new Cu(II), Co(II) complexes of isocoumarin derivative is elucidated, and metal (II) complexes with isocoumarin ligands represent a novel class of antioxidant agents which deserves further attention to be used as bioactive agents.

Author(s): Manali Rajeshirke, Rachi Shah, Poonam Yadav and Nalini V Purohit

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