Studies on diuretic activity of three plants from Menispermaceae family

This study evaluated the comparative diuretic potential of methanolic root extracts of Cissampelos pareira, Cyclea peltata and Stephania japonica (Fam: Menispermaceae) in saline primed normal rats after oral administration. Methanolic root extracts of Cissampelos pareira, Cyclea peltata and Stephania japonica (100 and 200 mg/kg P.O) or the reference drug, furosemide (20 mg/kg P.O) were administrated to male Wistar rats (Modified Lipschitz method) and their urine output and electrolyte changes were quantitated at several intervals of time after the dose for 5 h. All the extracts displayed dose-dependent diuretic effects. At 100mg/kg both Cyclea peltata and Stephania japonica root extracts shown significant increase in urinary out put (p < 0.001). However At 200 mg/kg dose all the three extracts significantly increased (p < 0.001) urine volume and urinary electrolytes, qualitatively similar to that of furosemide. The methanolic root extract of Cyclea peltata has shown highest diuretic activity (Diuretic action – 3.5). These findings collectively indicate that the extracts exhibited significant diuretic activity, providing evidence, at least in part, for their Aurvedic use. Especially root of Cyclea peltata has got highest diuretic action among three tested extracts. These results support the use of C. peltata roots as “Patha” in Ayurvedic system of medicine for the treatment of urinary related disorders.

Author(s): K.K Hullatti, M.S Sharada and I.J Kuppasth

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