We describe a 65-year-old patient with Vogt-Koyanagi-Harada (VKH) syndrome and primary malignant melanoma of the trunk presenting with systemic tumor progress and new contrast-enhancing intracranial lesions without neurological symptoms. While the systemic melanoma disease ultimately was in progress, the correct radiological interpretation of brain lesions as intracranial manifestation of VKH was mandatory to prevent the patient from unnecessary whole brain radiotherapy.
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